USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: GELS_HUMAN USC-OGP 2-DE database:  GELS_HUMAN GELS_HUMAN General information about the entry View entry in simple text format Entry name GELS_HUMAN Primary accession number P06396 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Gelsolin; AltName: Full=AGEL; AltName: Full=Actin-depolymerizing factor; Short=ADF; AltName: Full=Brevin; Flags: Precursor;. Gene name Name=GSN Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0170: pI=4.81; Mw=28095 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0287: pI=5.30; Mw=100574 SPOT OGP-0288: pI=5.75; Mw=99434 SPOT OGP-0290: pI=5.45; Mw=96090 SPOT OGP-0291: pI=5.60; Mw=95543 SPOT OGP-0293: pI=5.51; Mw=92858 SPOT OGP-0294: pI=5.57; Mw=91396 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0617: pI=5.46; Mw=95125 SPOT OGP-0619: pI=5.53; Mw=93758 SPOT OGP-0620: pI=5.60; Mw=92858 SPOT OGP-0621: pI=5.69; Mw=92858 SPOT OGP-0622: pI=5.63; Mw=91823 SPOT OGP-0623: pI=5.66; Mw=90293 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0860: pI=5.95; Mw=80837 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1112: pI=5.77; Mw=103924 SPOT OGP-1121: pI=5.77; Mw=83686 Cross-references UniProtKB/Swiss-Prot P06396; GELS_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GELS_HUMAN Primary accession number P06396 Secondary accession number(s) A2A418 A8MUD1 A8MYN7 B7Z373 B7Z5V1 F5H1A8 Q5T0I2 Q8WVV7 Sequence was last modified on  January 1, 1988 (version 1) Annotations were last modified on  March 15, 2017 (version 207) Name and origin of the protein Description RecName: Full=Gelsolin; AltName: Full=AGEL; AltName: Full=Actin-depolymerizing factor; Short=ADF; AltName: Full=Brevin; Flags: Precursor; Gene name Name=GSN Encoded on Name=GSN Keywords 3D-structure; Acetylation; Actin capping; Actin-binding; Alternative initiation; Alternative splicing; Amyloid; Amyloidosis; Calcium; Cilium biogenesis/degradation; Complete proteome; Corneal dystrophy; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Disulfide bond; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X04412; CAA28000.1; -; mRNA EMBL AK096280; BAG53247.1; -; mRNA EMBL AK125819; BAG54252.1; -; mRNA EMBL AK295572; BAH12109.1; -; mRNA EMBL AK299453; BAH13037.1; -; mRNA EMBL AK315494; BAG37878.1; -; mRNA EMBL AL137068; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AL513122; CAI14413.1; -; Genomic_DNA EMBL AL513122; CAM20459.1; -; Genomic_DNA EMBL CH471090; EAW87489.1; -; Genomic_DNA EMBL CH471090; EAW87490.1; -; Genomic_DNA EMBL CH471090; EAW87491.1; -; Genomic_DNA EMBL BC017491; AAH17491.1; -; mRNA EMBL BC026033; AAH26033.1; -; mRNA CCDS CCDS48011.1; -. [P06396-3]; . CCDS CCDS65118.1; -. [P06396-4]; . CCDS CCDS6828.1; -. [P06396-1]; . CCDS CCDS6829.1; -. [P06396-2]; . PIR A03011; FAHUP; . RefSeq NP_000168.1; NM_000177.4. [P06396-1]; . RefSeq NP_001121134.1; NM_001127662.1. [P06396-2]; . RefSeq NP_001121135.2; NM_001127663.1; . RefSeq NP_001121136.1; NM_001127664.1. [P06396-2]; . RefSeq NP_001121137.1; NM_001127665.1. [P06396-2]; . RefSeq NP_001121138.1; NM_001127666.1. [P06396-3]; . RefSeq NP_001121139.1; NM_001127667.1. [P06396-3]; . RefSeq NP_001244958.1; NM_001258029.1; . RefSeq NP_001244959.1; NM_001258030.1. [P06396-4]; . RefSeq NP_937895.1; NM_198252.2. [P06396-2]; . RefSeq XP_005252000.1; XM_005251943.1. [P06396-3]; . RefSeq XP_005252001.1; XM_005251944.1. [P06396-3]; . RefSeq XP_005252002.1; XM_005251945.3. [P06396-2]; . RefSeq XP_006717142.1; XM_006717079.1. [P06396-3]; . RefSeq XP_011516888.1; XM_011518586.1. [P06396-3]; . RefSeq XP_011516889.1; XM_011518587.2. [P06396-3]; . RefSeq XP_011516890.1; XM_011518588.2. [P06396-3]; . RefSeq XP_011516891.1; XM_011518589.2. [P06396-3]; . RefSeq XP_011516892.1; XM_011518590.2. [P06396-3]; . RefSeq XP_011516893.1; XM_011518591.2. [P06396-2]; . RefSeq XP_011516894.1; XM_011518592.1. [P06396-2]; . RefSeq XP_011516895.1; XM_011518593.1. [P06396-2]; . RefSeq XP_016870135.1; XM_017014646.1. [P06396-3]; . RefSeq XP_016870136.1; XM_017014647.1. [P06396-3]; . RefSeq XP_016870137.1; XM_017014648.1. [P06396-3]; . UniGene Hs.522373; -; . PDB 1C0F; X-ray; 2.40 A; S=53-176 PDB 1C0G; X-ray; 2.00 A; S=53-176 PDB 1D4X; X-ray; 1.75 A; G=52-177 PDB 1DEJ; X-ray; 2.40 A; S=53-176 PDB 1EQY; X-ray; 2.30 A; S=52-176 PDB 1ESV; X-ray; 2.00 A; S=52-176 PDB 1H1V; X-ray; 3.00 A; G=439-769 PDB 1KCQ; X-ray; 1.65 A; A=185-288 PDB 1MDU; X-ray; 2.20 A; A/D=52-176 PDB 1NLV; X-ray; 1.80 A; G=52-176 PDB 1NM1; X-ray; 1.80 A; G=52-176 PDB 1NMD; X-ray; 1.90 A; G=52-176 PDB 1P8X; X-ray; 2.00 A; A/B/C=439-782 PDB 1P8Z; X-ray; 2.60 A; G=52-187 PDB 1SOL; NMR; -; A=177-196 PDB 1T44; X-ray; 2.00 A; G=55-179 PDB 1YAG; X-ray; 1.90 A; G=52-176 PDB 1YVN; X-ray; 2.10 A; G=52-176 PDB 2FF3; X-ray; 2.00 A; A=52-179 PDB 2FF6; X-ray; 2.05 A; G=52-179 PDB 2FH1; X-ray; 1.55 A; A/B/C=439-782 PDB 2FH2; X-ray; 2.50 A; A/B/C=439-782 PDB 2FH3; X-ray; 2.87 A; A/B/C=439-782 PDB 2FH4; X-ray; 3.00 A; A/B/C=439-782 PDB 3A5L; X-ray; 2.40 A; S=53-176 PDB 3A5M; X-ray; 2.40 A; S=53-176 PDB 3A5N; X-ray; 2.36 A; S=53-176 PDB 3A5O; X-ray; 2.40 A; S=53-176 PDB 3CI5; X-ray; 1.70 A; G=52-176 PDB 3CIP; X-ray; 1.60 A; G=52-176 PDB 3CJB; X-ray; 3.21 A; G=52-176 PDB 3CJC; X-ray; 3.90 A; G=52-176 PDB 3FFK; X-ray; 3.00 A; A/D=52-426 PDB 3FFN; X-ray; 3.00 A; A/B=1-782 PDB 3TU5; X-ray; 3.00 A; B=53-174 PDB 4PKG; X-ray; 1.80 A; G=52-176 PDB 4PKH; X-ray; 2.15 A; B/E/G/J=52-176 B/E/G/J=196-260 PDB; 4PKI; X-ray; 2.30 A G=52-176 PDB; 4S10; X-ray; 2.61 A C/D=186-288 PDB; 4Z94; X-ray; 2.40 A G=52-176 PDB; 5DD2; X-ray; 2.60 A A/G=55-188 PDB; 5FAE; X-ray; 1.70 A A=178-293 PDB; 5FAF; X-ray; 1.05 A A=178-293 PDBsum; 1C0F; -; . PDBsum 1C0G; -; . PDBsum 1D4X; -; . PDBsum 1DEJ; -; . PDBsum 1EQY; -; . PDBsum 1ESV; -; . PDBsum 1H1V; -; . PDBsum 1KCQ; -; . PDBsum 1MDU; -; . PDBsum 1NLV; -; . PDBsum 1NM1; -; . PDBsum 1NMD; -; . PDBsum 1P8X; -; . PDBsum 1P8Z; -; . PDBsum 1SOL; -; . PDBsum 1T44; -; . PDBsum 1YAG; -; . PDBsum 1YVN; -; . PDBsum 2FF3; -; . PDBsum 2FF6; -; . PDBsum 2FH1; -; . PDBsum 2FH2; -; . PDBsum 2FH3; -; . PDBsum 2FH4; -; . PDBsum 3A5L; -; . PDBsum 3A5M; -; . PDBsum 3A5N; -; . PDBsum 3A5O; -; . PDBsum 3CI5; -; . PDBsum 3CIP; -; . PDBsum 3CJB; -; . PDBsum 3CJC; -; . PDBsum 3FFK; -; . PDBsum 3FFN; -; . PDBsum 3TU5; -; . PDBsum 4PKG; -; . PDBsum 4PKH; -; . PDBsum 4PKI; -; . PDBsum 4S10; -; . PDBsum 4Z94; -; . PDBsum 5DD2; -; . PDBsum 5FAE; -; . PDBsum 5FAF; -; . ProteinModelPortal P06396; -; . SMR P06396; -; . BioGrid 109189; 87; . DIP DIP-2196N; -; . IntAct P06396; 49; . MINT MINT-5000481; -; . STRING 9606.ENSP00000362924; -; . DrugBank DB02621; Latrunculin A; . iPTMnet P06396; -; . PhosphoSitePlus P06396; -; . SwissPalm P06396; -; . BioMuta GSN; -; . DMDM 121116; -; . OGP P06396; -; . EPD P06396; -; . PaxDb P06396; -; . PeptideAtlas P06396; -; . PRIDE P06396; -; . DNASU 2934; -; . Ensembl ENST00000373818; ENSP00000362924; ENSG00000148180. [P06396-1]; . Ensembl ENST00000373823; ENSP00000362929; ENSG00000148180. [P06396-2]; . Ensembl ENST00000545652; ENSP00000445823; ENSG00000148180. [P06396-4]; . GeneID 2934; -; . KEGG hsa:2934; -; . UCSC uc004ble.1; human. [P06396-1]; . CTD 2934; -; . DisGeNET 2934; -; . GeneCards ENSG00000283430; -; . GeneCards GSN; -; . HGNC HGNC:4620; GSN; . HPA CAB010823; -; . HPA CAB016728; -; . HPA CAB036009; -; . HPA HPA054026; -; . MalaCards GSN; -; . MIM 105120; phenotype; . MIM 137350; gene; . neXtProt NX_P06396; -; . OpenTargets ENSG00000148180; -; . OpenTargets ENSG00000283430; -; . Orphanet 85448; Familial amyloidosis; Finnish type; . PharmGKB PA29011; -; . eggNOG KOG0443; Eukaryota; . eggNOG ENOG410XR0A; LUCA; . GeneTree ENSGT00760000119111; -; . HOGENOM HOG000233630; -; . HOVERGEN HBG004183; -; . InParanoid P06396; -; . KO K05768; -; . OMA ANMEERK; -; . OrthoDB EOG091G05SC; -; . PhylomeDB P06396; -; . TreeFam TF313468; -; . Reactome R-HSA-264870; Caspase-mediated cleavage of cytoskeletal proteins; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-977225; Amyloid fiber formation; . SIGNOR P06396; -; . ChiTaRS GSN; human; . EvolutionaryTrace P06396; -; . GeneWiki Gelsolin; -; . GenomeRNAi 2934; -; . PMAP-CutDB P06396; -; . PRO PR:P06396; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000148180; -; . CleanEx HS_GSN; -; . ExpressionAtlas P06396; baseline and differential; . Genevisible P06396; HS; . GO GO:0030478; C:actin cap; IDA:UniProtKB; . GO GO:0015629; C:actin cytoskeleton; TAS:ProtInc; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0030864; C:cortical actin cytoskeleton; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; IDA:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0002102; C:podosome; IDA:UniProtKB; . GO GO:0016528; C:sarcoplasm; IDA:UniProtKB; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0003779; F:actin binding; IDA:UniProtKB; . GO GO:0005509; F:calcium ion binding; IMP:UniProtKB; . GO GO:0045159; F:myosin II binding; IPI:UniProtKB; . GO GO:0019904; F:protein domain specific binding; IPI:UniProtKB; . GO GO:0051693; P:actin filament capping; IMP:UniProtKB; . GO GO:0030041; P:actin filament polymerization; IDA:UniProtKB; . GO GO:0090527; P:actin filament reorganization; IGI:UniProtKB; . GO GO:0051014; P:actin filament severing; IDA:UniProtKB; . GO GO:0045010; P:actin nucleation; IEA:InterPro; . GO GO:1990000; P:amyloid fibril formation; IMP:UniProtKB; . GO GO:0051016; P:barbed-end actin filament capping; TAS:ProtInc; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0060271; P:cilium assembly; IMP:UniProtKB; . GO GO:0097284; P:hepatocyte apoptotic process; IMP:UniProtKB; . GO GO:0046597; P:negative regulation of viral entry into host cell; IMP:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0006911; P:phagocytosis; engulfment; ISS:UniProtKB GO GO:0051127; P:positive regulation of actin nucleation; IMP:UniProtKB; . GO GO:2001269; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:UniProtKB; . GO GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB; . GO GO:1902174; P:positive regulation of keratinocyte apoptotic process; IMP:UniProtKB; . GO GO:1903923; P:positive regulation of protein processing in phagocytic vesicle; ISS:UniProtKB; . GO GO:0031648; P:protein destabilization; IMP:UniProtKB; . GO GO:1903903; P:regulation of establishment of T cell polarity; IMP:UniProtKB; . GO GO:1903906; P:regulation of plasma membrane raft polarization; IMP:UniProtKB; . GO GO:0071801; P:regulation of podosome assembly; IMP:UniProtKB; . GO GO:1903909; P:regulation of receptor clustering; IMP:UniProtKB; . GO GO:1903689; P:regulation of wound healing; spreading of epidermal cells; IMP:UniProtKB GO GO:0097017; P:renal protein absorption; IMP:UniProtKB; . GO GO:0042989; P:sequestering of actin monomers; IMP:UniProtKB; . GO GO:0014891; P:striated muscle atrophy; IMP:UniProtKB; . Gene3D 3.40.20.10; -; 6; . InterPro IPR029006; ADF-H/Gelsolin-like_dom; . InterPro IPR030004; Gelsolin; . InterPro IPR007123; Gelsolin-like_dom; . InterPro IPR007122; Villin/Gelsolin; . PANTHER PTHR11977; PTHR11977; 1; . PANTHER PTHR11977:SF66; PTHR11977:SF66; 1; . Pfam PF00626; Gelsolin; 6; . PRINTS PR00597; GELSOLIN; . SMART SM00262; GEL; 6; .

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